Systemic sclerosis-associated fibrosis
نویسندگان
چکیده
منابع مشابه
Gadolinium-associated nephrogenic systemic fibrosis.
Nephrogenic systemic fibrosis is a progressive, potentially fatal multiorgan system fibrosing disease related to exposure of patients with renal failure to the gadolinium-based contrast agents used in magnetic resonance imaging. Because of this relationship between nephrogenic systemic fibrosis and gadolinium-based contrast agents, the U.S. Food and Drug Administration currently warns against u...
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Fibrosis of the lung, a common complication of systemic sclerosis (SSc) and the hallmark of idiopathic pulmonary fibrosis (IPF), is associated with substantial mortality and has no approved therapy. Despite some degree of overlap in their clinical features and pathogenesis, SSc-associated interstitial lung disease (ILD) and IPF have differences, with significant implications for diagnosis, eval...
متن کاملThrombin-mediated cellular events in pulmonary fibrosis associated with systemic sclerosis (scleroderma).
The vascular hypothesis for the pathogenesis of systemic sclerosis was perhaps Professor LeRoy's most important scientific contribution. One early and important consequence of vascular injury is the release of activated thrombin. In this manuscript we present our data and review the current understanding of the role played by thrombin in the process of fibrosis, particularly as it relates to sc...
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OBJECTIVE To investigate the association between serum levels and clinical signs of lung fibrosis in patients with systemic sclerosis and inflammatory myopathies. METHODS ELISA tests for a mucin-like glycoprotein KL-6, von Willebrandt factor (vWF), soluble E-selectin (sES) and surfactant protein D (SP-D) were performed in sera of 104 patients with systemic sclerosis, 31 patients with poly/der...
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In the enhancer region of the human type I collagen alpha 2 (COL1A2) gene, we identified cis-elements for the transcription factor CUX1. However, the role of CUX1 in fibrosis remains unclear. Here we investigated the role of CUX1 in the regulation of COL1 expression and delineated the mechanisms underlying the regulation of COL1A2 expression by CUX1 in systemic sclerosis (SSc) lung fibroblasts....
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2015
ISSN: 1040-8711
DOI: 10.1097/bor.0000000000000219